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KMID : 0362720150530050348
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Journal of the Korean Dental Association
2015 Volume.53 No. 5 p.348 ~ p.359
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Application of rhBMP-2 loaded collagen membrane on the buccal plate for ridge preservation: a pilot study in dogs
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Lim Hyun-Chang
Kim Min-Soo
Yang Cheryl
Lee Jung-Seok
Choi Seong-Ho
Jung Ui-Won
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Abstract
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Objective: The aim of this study was to determine the effect of multi-layer of a collagen membrane alone or loaded rhBMP-2 on the buccal plate for ridge preservation after tooth extraction.
Material and methods: Following bilateral extraction of the maxillary 1st and 3rd premolars in five dogs, rhBMP-2 loaded
collagen membrane was applied to the buccal plates at the 1st premolar and collagen membrane only was applied to the buccal plates at the 3rd premolar unilaterally. The collagen membranes applied in the experimental groups were piled into four layers. The corresponding sites of the contralateral side healed naturally. After 3months of healing, the animals were sacrificed. Radiographic and histologic analyses were performed.
Results: There was no significant difference in the healing of extraction socket at both 1st and 3rd premolars. In microcomputed tomography, the widths of the residual ridge of the experimental groups were similar with the controls. Histologically, the experimental groups did not exhibit different pattern compared to the controls regardless of the addition of rhBMP-2.
Conclusion: Layering of the collagen membrane with or without rhBMP-2 on the buccal plate failed to show the effectiveness in dimensional preservation of the extraction socket.
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KEYWORD
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collagen membrane, rhBMP-2, ridge preservation, ridge resorption
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